4% of the daily averaged gross domestic product (GDP) of the YRD. Emission control (in accordance with the 13th Five-year Energy Conservation and Emission Reduction Plan) is an effective way to reduce health risks in the YRD, reducing premature deaths during haze days by 12-33%. More stringent emission control measures are suggested for further reduce PM2.5-related health risks.Benthic microbes play a crucial role in maintaining the biogeochemical balance of aquatic ecosystems especially the material cycling during plant decomposition. However, those systems in agricultural area are always threatened by agricultural run-off containing a mass of typical pathogenic invader- Escherichia coli. It is therefore vital to clarify the turnover, assembly, and geochemical functions of the E. coli invaded benthic prokaryotic microbial community during plant decomposition. During the decaying process, the key filtering factors of benthic community assembly were NH4+-N (P less then 0.001), NO2--N (P less then 0.01), and Organic-N (P less then 0.05). The E. coli colonized significantly in sediments (P less then 0.001) and drove the turnover of the bacterial community (P = 0.001), which enhanced archaeal dominance in the benthic microbial network. E. coli also triggered niche structural variations. The biomass (%) of benthic nutrient cycling genera including Dechloromonas, Pseudomonas, Bacteroides, Candidatus_Methanofastidiosum, and Desulfomicrobium (P less then 0.05) was altered by E. coli stress. The structural equation model illustrated that E. coli critically affected the benthic microbial geochemical functions in multiple pathways (P less then 0.05). Our results provide new insights into benthic prokaryotic microbial community assembly and nutrient cycling and management under pollution stress.The concentrations of PBDEs, NBFRs, DP, PCBs, and OCPs were analyzed in water samples of the Yellow River Basin (YRB) and in soil and maize samples collected from basin irrigation areas to understand the status of POPs and associated health risks. The results showed (1) the congeners of eight PBDEs and seven NBFRs were detected in 10 tributaries, with average concentrations of 1575 and 4288 pg. L-1. Thirty-three congeners of PCBs were detected, and the average concentration of PCB was 232 pg. L-1. Five HCHs were the primary congeners among twenty-three congeners of OCPs in the ten tributaries, accounting for 79% of the total. The average concentration of OCPs was 8287 pg. L-1. (2) Similar congeners of HFRs, PCBs, and OCPs were found in the trunk water. The ranking based on the HFR concentration was upstream &gt; downstream &gt; midstream, and that of the PCB and OCP concentration was downstream &gt; upstream &gt; midstream. https://www.selleckchem.com/products/avitinib-ac0010.html (3) PCBs and OCPs in the trunk water of the YRB and in the soil and maize irrigated with river water pose potential carcinogenic and non-carcinogenic risks. The results indicate considerable organic pollution in the YRB, suggesting that national emission standards for POPs should be implemented soon.Exposure to fine particulate matter (PM2.5) has been associated with a higher risk for coronary events. Elevated circulating cardiac troponins (cTn) are suggestive of myocardial injury in both ischemic and non-ischemic conditions. However, little is known about the association between PM2.5 and cTn. In this study, we investigated short-term PM2.5 effects on cardiac troponin T (cTnT), as well as N-terminal-pro brain natriuretic peptide (NT-pro BNP) and inflammatory biomarkers among cardiac catheterized participants. We analyzed 7444 plasma cTnT measurements in 2732 participants who presented to Duke University Hospital with myocardial infarction symptoms between 2001 and 2012, partly along with measurements of NT-pro BNP and inflammatory biomarkers. Daily PM2.5 concentrations were predicted by a neural network-based hybrid model and were assigned to participants' residential addresses. We applied generalized estimating equations to assess associations of PM2.5 with biomarker levels and the risk of a positive cTnT test (cTnT &gt; 0.1 ng/mL). The median plasma cTnT concentration at presentation was 0.05 ng/mL and the prevalence of a positive cTnT test was 35.4%. For an interquartile range (7.6 μg/m3) increase in PM2.5 on the previous day, cTnT concentrations increased by 7.7% (95% CI 3.4-12.3) and the odds ratio of a positive cTnT test was 1.08 (1.01-1.16). Participants under 60 years (effect estimate 15.2%; 95% CI 7.4-23.5) or living in rural areas (12.3%; 95% CI 4.8-20.3) were more susceptible. There was evidence for increases in fibrinogen and NT-pro BNP associated with elevated PM2.5 on the concurrent and previous two days. Our study suggests that acute PM2.5 exposure may elevate indicators of myocardial tissue damage. This finding substantiates the association of air pollution exposure with adverse cardiovascular events.Climbazole (CBZ) ubiquitously detected in the aquatic environment may disrupt fish reproductive function. Thus far, the previous study has focused on its transcriptional impact of steroidogenesis-related genes on zebrafish, but the underlying toxic mechanism still needs further investigation at the metabolic level. In this study, adult zebrafish were chronically exposed to CBZ at concentrations of 0.1 (corresponding to the real concentration in surface water), 10, and 1000 μg/L and evaluated for reproductive function by egg production, with subsequent ovarian tissue samples taken for histology, metabolomics, and other biochemical analysis. After 28 days' exposure, fecundity was significantly decreased in all exposure groups, with the inhibition of oocytes in varying developmental stages to a certain degree. The decrease in retinoic acid and sex hormones, down-regulated genes important in steroidogenesis, and increase in oxidized/reduced glutathione ratio and occurrence of apoptotic cells were observed in zebrafish ovaries following exposure to CBZ even at environmentally realistic concentrations, suggesting that alternations in steroidogenesis and oxidative stress can play significant roles in CBZ-triggered reproductive toxicity. Besides, mass spectrometry imaging analysis validated the results from metabolomics analysis. Our findings provide novel perspectives for unveiling the mechanism of reproductive dysfunction by CBZ and highlight its risk to fish reproduction.